Dry granulator is a common problem in the pharmaceutical field
2023-03-08 08:10:59
1. The problem of large dust production
This is mainly due to the problem of equipment structure design. Many manufacturers design the equipment relatively simple and do not consider the problem of dust particles. This needs to be updated from the specifications and concepts of pharmaceutical production. The structure needs to be adjusted to fully consider the production of medicines. The dust particles generated during the time guarantee the production environment. With the increase in GMP requirements and the introduction of the cGMP concept, pharmaceutical equipment must be modified to meet the requirements. Regarding dust production, there is also a need to pay attention to the vibration of the equipment. We know that vibration will increase the generation of dust particles and increase the diffusion of dust particles. Therefore, when manufacturing equipment, we must consider the overall structure and manufacturing precision. Find the source of vibration that causes vibration and reduce the vibration generated by the device.
2. The low yield problem <br> <br> This course has associated with the formulation of materials, but under the current circumstances many pharmaceutical companies use dry granulator of view, it is the main reason for the roll. Due to the different quenching process and surface conditioning process of the roll surface, there will be problems such as the relative busbar parallelism between the pair of rolls, the insufficient hardness, and the high temperature of the roll under high pressure, which causes many rolls to be used in the material after being used. After the pressing, the granules contained in the granules contain more fine powder, and the yield is drastically lowered, or the yield is not high at the beginning. Another reason is the structural design of the equipment. Many domestic pharmaceutical companies use dry granulators to produce Chinese medicine granules. Because Chinese medicine granules are easy to absorb moisture and stick, the materials tend to accumulate on the dry granulator and block the passage. When these problems occur. It is necessary to stop the cleaning, which not only affects the production efficiency, but also reduces the yield of finished products. Therefore, one of the main reasons for these problems is the technical problems of the processing technology of the rolls and the consideration based on the cost! This is a problem in the manufacture of domestic dry granulators. Of course, the poor cooling effect is also a cause. If the extrusion heat generated by the extrusion of the surface of the pressure roller cannot be effectively cooled, the material is prevented from being thermally bonded and stuck, and the yield is greatly reduced.
3. The problem of unstable pressure
One of the common problems of domestic dry granulators is pressure instability. The domestic production of dry granulators, the hydraulic system design is generally the oil pump is in continuous working state, often causing oil temperature rise, pressure instability, more important It will cause the molecular structure of the hydraulic oil to be destroyed. It is necessary to replace the hydraulic oil when the working time is less than 30 shifts. After running for a period of time, this failure will occur. This is the main reason for the design of the pressure oil circuit. This should be based on the material properties and process requirements of the material, and the oil circuit structure should be reasonably selected to take into account the pressure peak and fluctuation shock. In the operation, the fluctuation peak of the oil passage pressure is within a certain range, which is substantially close to a straight line. The Japanese friendship company's hydraulic system is relatively advanced, and some domestic manufacturers have adopted its structure.
4. Problems that are difficult to clean
Mainly due to structural design reasons. Manufacturers need to consider cleaning at the source of the design.
5. Roll problem
5.1. The surface structure of the roll is easy to be damaged. The main dimensional parameters are the number of circumferential teeth, the width of the tooth groove, and the depth of the tooth opening. Different roll surface structures have different pressing effects on the suitability of materials. According to different material characteristics, they can be generally divided into three kinds of pressure wheels: western medicine type, traditional Chinese medicine type and special material type.
The material of the roll is generally made of stainless steel iron 2Gr13, the surface is treated with gas nitriding technology, the surface hardness HV10 is above 1000°, and the depth of the nitriding hardened layer is above 0.15mm, so that the surface of the roll has strong wear resistance and fatigue strength. And has good corrosion resistance.
5.2. The problem of roll misalignment, which is actually a problem that occurs when the manufacturing pressure is not high due to high pressure.
5.3. Leakage The inside of the cooling water roll is supplied with cooling water. The rotating roll and the static cooling water pipe have a dynamic sealing device. However, after a long time of use, there is a problem of leakage under high pressure. At present, our factory has improved the roll structure, so that the cooling water directly reaches the surface of the pressure roller, which can effectively reduce the surface temperature of the roll and greatly reduce the possibility of leakage. It should be said that it is an improvement.
This is mainly due to the problem of equipment structure design. Many manufacturers design the equipment relatively simple and do not consider the problem of dust particles. This needs to be updated from the specifications and concepts of pharmaceutical production. The structure needs to be adjusted to fully consider the production of medicines. The dust particles generated during the time guarantee the production environment. With the increase in GMP requirements and the introduction of the cGMP concept, pharmaceutical equipment must be modified to meet the requirements. Regarding dust production, there is also a need to pay attention to the vibration of the equipment. We know that vibration will increase the generation of dust particles and increase the diffusion of dust particles. Therefore, when manufacturing equipment, we must consider the overall structure and manufacturing precision. Find the source of vibration that causes vibration and reduce the vibration generated by the device.
2. The low yield problem <br> <br> This course has associated with the formulation of materials, but under the current circumstances many pharmaceutical companies use dry granulator of view, it is the main reason for the roll. Due to the different quenching process and surface conditioning process of the roll surface, there will be problems such as the relative busbar parallelism between the pair of rolls, the insufficient hardness, and the high temperature of the roll under high pressure, which causes many rolls to be used in the material after being used. After the pressing, the granules contained in the granules contain more fine powder, and the yield is drastically lowered, or the yield is not high at the beginning. Another reason is the structural design of the equipment. Many domestic pharmaceutical companies use dry granulators to produce Chinese medicine granules. Because Chinese medicine granules are easy to absorb moisture and stick, the materials tend to accumulate on the dry granulator and block the passage. When these problems occur. It is necessary to stop the cleaning, which not only affects the production efficiency, but also reduces the yield of finished products. Therefore, one of the main reasons for these problems is the technical problems of the processing technology of the rolls and the consideration based on the cost! This is a problem in the manufacture of domestic dry granulators. Of course, the poor cooling effect is also a cause. If the extrusion heat generated by the extrusion of the surface of the pressure roller cannot be effectively cooled, the material is prevented from being thermally bonded and stuck, and the yield is greatly reduced.
3. The problem of unstable pressure
One of the common problems of domestic dry granulators is pressure instability. The domestic production of dry granulators, the hydraulic system design is generally the oil pump is in continuous working state, often causing oil temperature rise, pressure instability, more important It will cause the molecular structure of the hydraulic oil to be destroyed. It is necessary to replace the hydraulic oil when the working time is less than 30 shifts. After running for a period of time, this failure will occur. This is the main reason for the design of the pressure oil circuit. This should be based on the material properties and process requirements of the material, and the oil circuit structure should be reasonably selected to take into account the pressure peak and fluctuation shock. In the operation, the fluctuation peak of the oil passage pressure is within a certain range, which is substantially close to a straight line. The Japanese friendship company's hydraulic system is relatively advanced, and some domestic manufacturers have adopted its structure.
4. Problems that are difficult to clean
Mainly due to structural design reasons. Manufacturers need to consider cleaning at the source of the design.
5. Roll problem
5.1. The surface structure of the roll is easy to be damaged. The main dimensional parameters are the number of circumferential teeth, the width of the tooth groove, and the depth of the tooth opening. Different roll surface structures have different pressing effects on the suitability of materials. According to different material characteristics, they can be generally divided into three kinds of pressure wheels: western medicine type, traditional Chinese medicine type and special material type.
The material of the roll is generally made of stainless steel iron 2Gr13, the surface is treated with gas nitriding technology, the surface hardness HV10 is above 1000°, and the depth of the nitriding hardened layer is above 0.15mm, so that the surface of the roll has strong wear resistance and fatigue strength. And has good corrosion resistance.
5.2. The problem of roll misalignment, which is actually a problem that occurs when the manufacturing pressure is not high due to high pressure.
5.3. Leakage The inside of the cooling water roll is supplied with cooling water. The rotating roll and the static cooling water pipe have a dynamic sealing device. However, after a long time of use, there is a problem of leakage under high pressure. At present, our factory has improved the roll structure, so that the cooling water directly reaches the surface of the pressure roller, which can effectively reduce the surface temperature of the roll and greatly reduce the possibility of leakage. It should be said that it is an improvement.
Vitamins are a type of trace organic substances that humans and animals must obtain from food in order to maintain normal physiological functions. They play an important role in human growth, metabolism and development. Vitamins do not participate in the formation of human cells in the body, nor do they provide energy for the human body. Vitamins are a class of organic compounds necessary for maintaining good health.
Our company provides group A vitamins, group B vitamins, B12, etc.
Vitamin Tablet,Food Grade Vitamin,Vitamins For Energy,Water Soluble Vitamins
XI AN RHINE BIOLOGICAL TECHNOLOGY CO.,LTD , https://www.rhinebioteches.com