Scientists discover new ways to prevent and treat type 1 diabetes
Release date: 2015-01-26
Recently, Dr. Thomas Burris of St. Louis University reported a new method for preventing type 1 diabetes in a mouse model in a study published in the journal Endocrinology.
Type 1 diabetes is a chronic autoimmune disease, and its own immune system can damage insulin-producing beta cells, making it unable to secrete insulin normally, leading to insulin deficiency and high blood sugar. At present, the main treatment for type 1 diabetes is to control blood sugar levels through insulin therapy, which is often accompanied by the patient's life.
Burris and his team focused on blocking the autoimmune process of damaged beta cells in order to develop treatments that prevent disease, rather than post-onset treatment. He said: "No mice in our trial developed diabetes, even if we were treated after significant damage to beta cells. We believe that this treatment will slow the progression of type 1 diabetes and may even lift insulin. The need for therapy."
Scientists have known that at least two types of T lymphocytes are involved in the development of type 1 diabetes, however, the role of another type of helper T cell (T helper cell 17, Th17) is currently unclear.
In this study, the researchers found that two nuclear receptors play an important role in the development of Th17, namely ROR-α and ROR-γt. They used Burris to invent a selective inverse agonist SR1001 to target these two receptors, successfully blocking autoimmunity in mouse models and protecting beta cells.
These results confirm that Th17 cells may play an important role in the development of type 1 diabetes, and that the use of drugs to target this cell type may become a new strategy for the treatment of diabetes.
Source: biodiscover
Tablet Candy,Confectionery Tablet,Replenish Blood Tablets,Ganoderma Lucidum Capsules
Guangzhou Etechange Biological Engineering Co.,Ltd. , https://www.etechange.com