Japanese scientists use genetically modified pigs to explore diabetes mechanisms
Japanese researchers have used GM technology to reproduce complications such as diabetes and retinopathy and kidney failure in pigs. Reproducing these diseases in large mammals will help to study the mechanisms that cause complications and the corresponding treatments.
According to "Nikkei Business News" reported on May 29, insufficient insulin secretion in the human body to lower blood sugar levels can lead to diabetes. Hyperglycemia damages blood vessels and nerves, causing complications, and in severe cases, blindness or kidney failure.
A research team at Meiji University in Japan used the latest genetic engineering techniques to transfer pigs to genes that cause diabetes in humans, reducing pig insulin secretion and developing diabetes. Through long-term feeding observations, the blood vessels of sick pigs also became weak; the symptoms of retinal hemorrhage continued to increase, and cataracts also appeared; the kidneys also experienced symptoms of depletion.
The research team said that the previous studies on diabetes drugs mainly used experimental mice, but because the weight and longevity of the experimental mice are quite different from those of humans, the drug development effect is not as close to human use as the size and blood sugar level of pigs. Mammal. The GM pig model developed by the team is more suitable for related research and will help to clarify the mechanisms of diabetes and complications.
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