Research team successfully rewrites large genomes by synthesizing DNA
Scientists are eager to use customized organisms to fight disease and even build new computers. However, there is a big difficulty: it is very difficult to completely change the genes, and it is impossible to accurately create the life forms that humans want.
However, I have just learned that a foreign research team has successfully found a way to rewrite large segments of the genome through synthetic DNA. The team used a step-by-step recombination approach to implant yeast growth genes into Salmonella to improve its quality. This experiment successfully replaced 1557 nodes distributed over 176 genes. For a simple creature like Salmonella, it can be said that it has changed dramatically.
The Salmonella obtained by this method is basically normal. Its growth rate is consistent with natural varieties, and no major growth defects have been found.
This research is still in its early stages, so no customized bacteria will appear in your body in a short time. The genes for Salmonella are relatively easy to edit, and there are many differences between laboratory results and the process of truly establishing a stable production of specific bacteria. However, the results of this experiment let us see hope. CRISPR-like gene editing techniques do not have enough throughput to rewrite genes on a large scale, and other methods are slow and complex. The new method at least proves that geneticists have the ability to quickly and thoroughly edit genes, and it is expected to completely release the great potential of genetic engineering.
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