Application and development of centrifugal extractor in the pharmaceutical field
In recent years, the domestic pharmaceutical industry to implement reform, centrifugal extractor machine for the production of a higher requirement. Under the premise of maintaining the separation characteristics of the centrifugal extractor, it is also necessary to meet the requirements of the "Good Manufacturing Practices", "General Rules for Pharmaceutical Equipment in Accordance with Good Manufacturing Practices" and "Guidelines for the Validation of Pharmaceutical Machinery (Equipment)". At the same time, the surface of the equipment directly contacting the drug inside the centrifugal extractor should be smooth, flat, free from dead angles, easy to clean or have purification, sterilization, corrosion resistance, chemical reaction without drugs or adsorption of drugs.
Today, centrifugal extractors are used in a wide range of applications in the medical field. Such as blood separation, virus research, DNA research, drug purification, hydrometallurgy, flavor material extraction, wastewater treatment, etc. are widely used in centrifugal extraction machines. The pharmaceutical centrifugal extractor has the characteristics of good adaptability, high degree of automation, stable operation, strong processability, good corrosion resistance, good operating environment, complete and reliable safety protection device and beautiful appearance.
It is understood that the centrifugal extractor used in the refining process such as drug purification is generally a CWL-M centrifugal extractor with a rotational speed of 4000 r/min or less. It has the advantages of large processing capacity and good phase separation. The quality of production and production of pharmaceuticals is closely related to the factors of pharmaceutical equipment. In order to meet the GMP specifications and requirements in the production of pharmaceuticals, flat-type stainless steel materials and materials with anti-corrosion properties are generally used.
From a functional point of view, the four advantages of a pharmaceutical centrifugal extractor :
1. The adaptability of the material is strong. The appropriate filter medium can be used to separate the fine particles of the millimeter level. It can also be used for the dehydration of the finished articles, and the articles can be cleaned by the water washing tube.
2. The pharmaceutical centrifugal extracting machine is mostly the upper unloading structure, and the artificial upper unloading type structure is simple, the installation aspect, the cost input is low, the operation is easy, and the grain shape of the product can be maintained.
3. The machine adopts advanced elastic support structure, which can reduce the vibration caused by uneven load and balance the stability of machine operation.
4. The entire high-speed operation structure is concentrated in a closed structural shell, effectively avoiding contamination of materials.
Centrifugal extraction machine extraction principle
The operation of extracting a certain component from a liquid mixture with a solvent is referred to as liquid/liquid extraction. Centrifugal extractor extraction is the use of the difference in solubility of the components in the solution in the selected solvent, so that the solute is liquid-mass transferred to achieve the separation of the homogeneous liquid mixture. The entire extraction process of the centrifugal extractor can include:
1. The raw material liquid and the extracting agent are thoroughly mixed and contacted to complete the solute mass transfer process;
The light and heavy two-phase solution enters the annulus-type mixing zone formed between the rotating drum and the casing from the two feeding nozzles in a certain proportion, and the two phases are quickly mixed and dispersed by the rotation of the rotating drum through the turbine disk and the impeller The two-phase solution is fully mass-transferred. Complete the mixed mass transfer process.
2. a separation process of the extract phase and the raffinate phase;
The mixed liquid enters the rotating drum under the action of the vortex disk. In the compartment formed by the blessing plate, the mixed liquid quickly rotates synchronously with the rotating drum. Under the action of centrifugal force, the heavy phase liquid is gradually stepped in the upward flow process. Keep away from the center of the drum and lean toward the drum wall; the light phase liquid with a small specific gravity gradually moves away from the drum wall to the center, and the clarified two-phase liquid finally enters the collection chamber through the respective jaws and is taken out of the machine separately by the guide tube. , complete the two-phase separation process.
3. The process of recovering the extractant from the extract phase and the raffinate phase.
The extractant is usually recovered by distillation. The extract phase after removal of the extractant is referred to as an extract; the raffinate phase after removal of the extractant is referred to as a raffinate.
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