This medical test technology can help you quickly find heart disease

Cardiac troponin I and cardiac troponin T are the two most effective indicators for determining the presence or absence of damage to the heart. After 80% of patients have a heart attack, they will develop symptoms of increased cardiac troponin I levels in their blood within two to three hours of being sent to the emergency room.

Cardiac troponin is released into the bloodstream when myocardial cell damage or necrosis is also the most sensitive and clear indicator of our diagnosis of severe cardiovascular injury. So, can it serve as an early indication of early warning of such damage?

It is in this hope that the medical community has conducted a series of innovative research in recent years around cardiac troponin and a series of highly sensitive indication proteins. The ideal goal is that if we can measure the level of micro-cardiac troponin in normal humans, we can detect incremental changes in cardiac troponin levels over time, leading to early heart failure or early ischemia. Early warning of sexual diseases, for patients to gain valuable time to delay or reverse the disease.

有了这项技术,就能早早发现心脏病

For example, Quanterix has developed a highly sensitive protein detector called Simoa. The company's CEO and executive chairman Kevin Khrushovsky said: "Now, most of the technology that can see proteins in the blood. Can also see signs of disease, but they do not see signs of health. And this continuity is very important, because if we can find any level of deviation from the baseline level of these sensitive protein levels, and can be very early When we detect it, we can find any signs of unhealthy."

Simoa puts 500,000 tiny "beads" that bind antibodies into blood samples. These beads will stir back and forth in the blood sample, and when they encounter a particular type of protein, they will "stick" like a Velcro. Then Simoa will put in a second antibody that will fluoresce when it encounters a specific protein (that is, the complex produced in the previous round). The beads are then rolled onto a Sony-made disc that has 212,000 holes dug in size and is only a little larger than the beads. After the beads are all rolled into the hole, the laser camera scans each hole to see if the beads are fluorescent. Even if only one hole of a small hole fluoresces, Simoa can detect it—that is, it can find a single target protein in the “ocean” of the blood, with the ability to “needle in a haystack”.

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