China University of Science and Technology develops nano drug delivery system to simultaneously kill breast cancer cells and cancer stem cells
Release date: 2016-07-18
Recently, Professor Wang Jun from the University of Science and Technology of China published a new research progress in the international academic journal Biomaterials. They found that the combination of autophagy inhibitory drugs and chemotherapeutic drugs can effectively kill breast cancer cells by means of nanoparticle transport system. And breast cancer stem cells, this study provides a new treatment for the treatment of breast cancer stem cells caused by treatment resistance and recurrence.
In the past decade, the concept of cancer stem cells has developed rapidly and has received increasing attention. Scientists believe that cancer stem cells play an important role in tumor initiation, progression and metastasis, recurrence, and drug resistance. Simultaneous elimination of a large number of tumor cells and a small number of cancer stem cell subsets may produce good therapeutic effects and ultimately lead to the relief of cancer conditions.
There is increasing evidence that autophagy plays an important role in cancer stem cell maintenance, plasticity and survival. In this study, the researchers studied how autophagy affects the susceptibility of breast cancer stem cells to chemotherapy drugs. They first sorted ALDHhi cells from the breast cancer cell line MDA-MB-231, using chloroquine (CQ, An autophagy inhibitor drug inhibits the autophagy process of cells, and results in a decrease in the dryness of breast cancer stem cells and an increase in susceptibility to chemotherapeutic drugs (DOX and DTXL).
In recent years, the field of nanomedicine has also made great progress, especially the drug delivery by means of the nanoparticle transport system has been proved in the treatment of various diseases. In this study, the researchers further demonstrated that nanoparticle-mediated autophagy inhibition in vitro can promote the therapeutic efficiency of chemotherapeutic drugs on ALDHhi MDA-MB-231 cells. Administration of the nano drug delivery system can significantly prolong the circulating half-life of both DOX and DTXL drugs, increasing the enrichment of drugs in tumor tissues and ALDHhi cells. More importantly, the researchers used MDA-MB-231 cells to establish a tumor orthotopic mouse model and found that CQ (NPCQ) and DOX (NPDOX) nanoparticles were combined separately compared to a single drug treatment. The use and packaging of both drugs in the same nano-transport system (NPCQ/DOX) simultaneously removes tumor cells and cancer stem cells, demonstrating more effective and sustained tumor growth inhibition.
Therefore, this study shows that the use of nanoparticle drug delivery system to simultaneously deliver autophagy inhibitory drugs and chemotherapeutic drugs to tumor sites can effectively exert a killing effect and is an effective strategy for the treatment of breast cancer.
Source: Bio Valley
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