BRCA1/2 under the star halo: I did a genetic test worth 3,999 yuan.
One of the important reasons for Julie's removal of bilateral breasts, ovaries and fallopian tubes is that Julie's blood test showed that she is a BRCA1 mutation carrier, and the risk of breast cancer is estimated to be 87%, and the risk of ovarian cancer There are 50%, and her mother, grandmother and aunt are all dying of cancer.
BRCA1/2 under the star halo
Angelina Jolie, the star, released such a message, and BRCA1/2 under this aura naturally attracted people's attention.
Readers who are not familiar with BRCA1/2 can start with the introduction of Professor Liu Qiang, deputy director of the Breast Cancer Department of Sun Yat-sen Memorial Hospital of Sun Yat-Sen University:
BRCA1 and BRCA2 are abbreviations for Breast Cancer Susceptibility Gene 1/2, breast cancer susceptibility genes 1 and 2. Both of these genes are tumor suppressor genes that encode proteins that produce tumor cell suppression.
Normal humans have a large number of cell renewals every day. A small amount of cancer cells will be produced in this process, but these cancer cells will soon be inhibited by the tumor suppressor gene or recognized by the immune system and will not form tumors.
BRCA1/2 protein is part of this line of defense. If their gene mutations lead to the loss of tumor suppressor function, the incidence of breast cancer, ovarian cancer or some other tumors will increase significantly. Because they are first discovered in breast cancer, they are called breast cancer susceptibility genes.
If you use the factory to make a simple metaphor for Julie, this is probably the case:
There is a factory with many assembly lines that produce parts every day. But after all, there are so many parts and high precision, it is inevitable that there will be some defective products. Therefore, two workers were arranged in the factory, and the parts produced on the assembly line were taken every day.
But good flowers don't open often, and good times don't always happen. Suddenly a worker on a certain assembly line was sick and took time off. That's no way, there are so many jobs, I still have to do it.
Another worker is too busy to come, because it is too tired, it will inevitably be misunderstood, and the defective rate will rise. It’s okay once or twice. If you work as a person for two people for a long time, you also know that the King’s King Kong can’t hold back, and the number of defective products is increasing. If there are many defective products in the entire assembly line, the factory will put a big deal on it, and it will even cause the entire factory to close down.
Therefore, what Julie is facing now is that she already knows that the same type of assembly line of many factories in the same department has already experienced such a situation, causing the entire factory to close down. Moreover, she also determined that there was a high probability that a worker would go to work on the assembly line. Therefore, in order to avoid the whole factory, she decided to stop the entire assembly line to ensure the smooth operation of the other assembly lines.
This is Julie's decision based on the family history and her own test results, but it also makes genetic testing into the eyes of many people. Genetic testing is a possibility to find out if a "worker" is sick.
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