The latentity of tuberculosis infection is associated with natural killer cells

2024-10-08 07:02:01

August 24, 2018 Source: Science and Technology Daily

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British "Nature" published an online epidemiological study on the 22nd: American scientists found that higher levels of natural killer cells (white blood cells that kill specific pathogens) are associated with latent tuberculosis. This raises the question of whether natural killer cells may play an important role in tuberculosis infection.

Tuberculosis is a bacterial disease that is also the leading cause of death from infection. Most tuberculosis infections are latent, that is, without external symptoms, and in a state that does not spread. It is estimated that one in four people worldwide is infected with latent tuberculosis, but less than 10% of latent tuberculosis cases eventually progress to active tuberculosis infection. Despite this, little is known about the immune factors that affect the outcome of an individual's infection.

To understand the underlying immune status and whether the condition will change after the disease progresses, the Stanford University School of Medicine conducted a number of cohort studies that combined a large number of cell counts with gene expression data sets to identify uninfected Try to compare the immune cell population between latent or active tuberculosis subjects.

They found that latent tuberculosis was associated with more natural killer cells, and latent tuberculosis subjects had stronger antitoxin responses than uninfected subjects. In the active tuberculosis test, the number of natural killer cells is small, but after the infection is cured, the number will be restored to the baseline level. Despite this, the above findings cannot prove a causal relationship between natural killer cells and latent tuberculosis.

In addition, the researchers showed that measuring natural killer cell levels can be used to determine the level of activity and burden of infection in patients with tuberculosis infection, and this finding may help to assess disease progression and optimize treatment options. (Reporter Zhang Mengran)

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