Heparin promotes food intake and weight gain
2023-09-06 15:11:20
Heparin promotes food intake and weight gain
September 07, 2017 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)]; Heparin is a substance widely used to prevent blood coagulation. It is developed and named based on natural anticoagulants in the body. However, according to a recent article published in the journal Cell Reports by researchers from Baylor College of Medicine and South China Agricultural University, heparin has been found to promote food intake and weight gain. This finding means that heparin may serve as a potential target for regulating appetite and controlling body weight.
"Our re-study found that heparin levels in the serum of mice are significantly increased under starvation, which led us to study the role of heparin in feeding control," said Gang Shu, a professor at the College of Animal Science at South China Agricultural University.
The researchers found that heparin activates a neuron called AgRP in the hypothalamus, one of the most important appetite-regulating neurons. Further, the expression level of a neuropeptide AgRP protein which is responsible for stimulating appetite is increased in neurons. Heparin also activates the release of electrical signals and chemical neurotransmitter signals from AgRP neurons. The researchers believe that these two types of effects together lead to an increase in the level of eating in mice.
"Interestingly, we have also shown that heparin can activate AgRP neurons by competitively binding insulin receptors with insulin." Shu said: "Insulin and heparin have opposite functions for AgRP neurons, and insulin can inhibit the activity of AgRP neurons. And AgRP can compete with it to activate neurons."
Although the above tests were performed at the mouse level, they still have potential therapeutic value for patients because heparin is a widely used anticoagulant. If it can be verified in human trials, it may bring good news to people who are eating disorders and overweight.
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