Lu Yinming, a pioneer in non-invasive DNA prenatal diagnosis: a controversy over the Han Chunyu incident

The DNA in the blood can screen for lymphoma and nasopharyngeal cancer, and can also monitor the rejection of organ transplants and the degree of injury to the injured? In the future, use the DNA in the urine to diagnose cancer?

This kind of thinking is not unconstrained, but from the first winner of the Future Science Award, known as the "China Nobel Prize", Lu Yuming.

Since the invention of non-invasive DNA prenatal diagnostic technology (hereinafter referred to as NIPT) five years ago, millions of pregnant women in more than 90 countries around the world do not need amniocentesis, and can perform prenatal fetal gene monitoring without trauma. Professor of Chinese University of Hong Kong Lu Yuming won the "Life Science Award" for the Future Science Award.

In an exclusive interview, he revealed his latest research results that have not yet been published: through the screening of 20,000 Hong Kong people through new technology, the probability of early detection of nasopharyngeal cancer is three times higher than before, and the mortality rate is expected to drop by half.

Now, Lu Yuming is gradually realizing his whimsy.

Lu Yuming and his non-invasive DNA prenatal technology.

Two months ago, Lu Yuming, who was nominated for the 2016 Nobel Prize in Physiology or Medicine, missed this honor.

Research inspiration

From instant noodles to Harry Potter

For others, there may be some loss. For Lu Yuming, it seems to be outside the game.

At the appointed interview time, Lu Yuming walked out of the lab and shook hands with a slightly implicit smile.

He just published a research paper last week. Every day, he will continue to brush online to see how many people read, and whether there is any scientific media to report this paper. This incident made him more nervous than whether he could win the prize.

Lu Yuming, born in Hong Kong, received his Ph.D. and his doctorate in medicine from Oxford University. Expert in clinical application of molecular biology. He is currently the Director of Li Ka-shing Health Science Research Institute of the Chinese University of Hong Kong, Li Ka-shing Medical Professor and Professor of Chemical Pathology.

In 2016, it was a good year for Lu Yuming. He became the first winner of the Future Science Awards, which was called the "China Nobel Prize." Also this year, he won the “Citation Award”, which has successfully predicted 39 Nobel Prize winners since 2002.

The two most famous passages on Lu Yuming's research are related to inspiration: one is that he took inspiration from his instant noodles, boiled the plasma, and found fetal DNA in the blood of pregnant women, thus inventing non-invasive DNA prenatal diagnosis (below) Referred to as NIPT), the pregnant woman does not have to use the risky amniocentesis technique during the birth check; the other is the capital letter "H" that flashed from the title when he watched the movie "Harry Potter" with his wife. Inspired to solve the problem of mapping human fetal genomes from maternal plasma.

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