The caudate nucleus is responsible for pessimism and is expected to open up new ways of treating depression.
[Global Network Comprehensive Report] According to the British "Daily Mail" reported on August 9, the MIT research team found that it can guide the negative reaction by stimulating the caudate nucleus of the animal's brain, thus proving the area. Mainly responsible for emotional decisions of pessimistic emotions. The study is expected to help scientists better understand and treat depression.
Researchers at the Massachusetts Institute of Technology and psychiatrists have found that stimulating the caudate nucleus of the animal's brain allows it to focus more on the negative side of things than on positive aspects, and this negative behavior will last a long time. Ann Graybiel, a professor at the MIT Institute, is a senior author of the study. She said that the caudate nucleus of the brain is closely related to anxiety and depression. Currently, the research results have been published in the journal Neuron.
The researchers used current to stimulate the caudate nucleus of the animal's brain. In addition, animals will receive the reward of juice in the experiment, and will also be stimulated by the aversion of the jet. The rate of each experiment reward and aversive stimulus is different, and the subject can choose whether to accept the reward. The researchers found that when rewards and aversive stimuli occur at the same frequency, animals choose to accept them; when rewards are less than stimuli, they reject them. However, when researchers stimulate the caudate nucleus, even if the frequency of rewards and aversive stimuli is the same, they will not accept it. Instead, they will pay more attention to the cost of aversion, and this reaction lasts for several days.
Dr. Grebiel is currently working with psychiatrists at the McLean Hospital in Boston, USA to find out if the caudate nucleus of patients with depression and anxiety has abnormal activity during emotional decision making. NMR showed abnormal activity in both regions of the anterior frontal cortex connecting the caudate nucleus. Experts believe that this phenomenon may disturb the activity of dopamine to some extent. (Wang Nan Liu Yang)
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