PNAS: Malignant tumors are "born bad"?
Release date: 2018-05-17
Image source: Pixabay
Thanks to the rapid development of screening technology, many small “precancerous†tumors have been detected, which facilitates timely intervention and reduces the mortality rate of advanced cancer, but it also faces the problem of overdiagnosis. Therefore, it is important to distinguish between benign and malignant tumors at an early stage.
In the latest study, scientists from Duke University and the University of Southern California used colorectal cancer as a case and found that invasive cancer is a type of "congenital bad."
Doi.org/10.1073/pnas.1716552115
The team recruited 19 patients with colorectal tumors and used mathematical multiscale models and multiregional sequencing to find differences in the early growth stages of benign and malignant tumors. Results The characteristics of early abnormal cell movement were found in most invasive tumor samples (9/15), which is required for tumor spread. They did not show any obvious signs of abnormal cell movement in 4 benign tumor samples.
The author of the article, Marc D. Ryser, said that many of the key features of the tumor have long been deep in the genome of the cell of origin. Therefore, they speculate that invasive tumors initially have the ability to spread, rather than develop with time. In other words, their bad "is born."
The researchers stressed that this study is small and still requires a larger sample size to validate this conclusion. But this finding is an important step in establishing a protocol to distinguish between benign and malignant tumors. In the future, this early abnormal cell movement is expected to be used in the diagnosis of cancer.
Editor: Aiman
Reference materials:
Deadly cancers show early, detectable differences from benign tumors
Source: Bio-Exploration
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