Live cells as sensors for electronic capsule exploration
For the first time, U.S. researchers used genetically modified living cells to make microsensors and then made capsules for probing gastrointestinal diseases.
Researchers at the Massachusetts Institute of Technology first genetically engineered an innocuous strain of E. coli to cause it to glow when it encounters heme in the bloodstream; millions of such strains are then filled into special sensors. Covered with a semi-permeable membrane. The phototransistor installed under the strain can measure the amount of light emitted by the bacterial cells and pass the information to the microprocessor, which sends the information wirelessly to a nearby computer or smartphone. Researchers have developed an "Android" system application that can analyze received information.
The cylindrical sensor is about 3.8 centimeters long and only about 13 microwatts of power is needed to operate. The sensor is equipped with a battery of 2.7 volts, which allows the sensor to run continuously for about one and a half months.
The researchers wrote in an article published in the latest issue of the journal Science that the experiment showed that after entering the pig's body, the capsule could accurately detect the signal of gastric bleeding. Their next step will be to investigate how to reduce the size of the sensor and develop more strains that are sensitive to inflammation, ulcers, and even cancer, for exploration of human gastrointestinal diseases.
One of the authors of the paper, Tim Guess, suspects that in the future, patients may only need to “eat a week or one month†of electronic capsules, and they will be able to replace traditional colonoscopy and explore the early symptoms of cancer as soon as possible. (Wang Xinfang)
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