Single-molecule manipulation tool: Lumicks latest laser diaphragm system M-Trap new product release

2023-10-12 13:12:01

The continuous development of single-molecule technology has greatly promoted the progress of life science research. The Dutch Lumicks company has been working on the field of single molecule manipulation. The latest product, M-Trap (laser diaphragm) will be launched soon, M- Trap will help scientists achieve even better results in the field of biological single molecules with its superior mechanical resolution and unparalleled stability!

M-TtrapTM (laser diaphragm) Main features: High resolution, ultra stable
Force resolution: <0.1 pN (100Hz)

Force stability: <0.3 pN over minutes

M-Trap official release date: November 23, 2017

To learn more, please click: https://lumicks.com/lumicks-coming-this-november/

C-trapTM (laser diaphragm) latest application case:
Cytoskeletal single molecule visualization

Dynamic changes in cells are the basis for life activities such as polarization, migration and division. These dynamic changes are triggered by physicochemical signals that the cells are subjected to, and eventually converted to mechanical signals that act on the cytoskeleton. The cytoskeleton is extremely plastic and can form bundles or nets, which ultimately determines the morphology of cells, the transport of intracellular substances, and maintains the stability and compliance of cells and tissues. These properties of the cytoskeleton are closely related to its basic structure. There are indirect methods and direct methods for the study of these cytoskeleton. The indirect method is to observe the cells or tissues by fluorescence microscopy. The direct method is a single molecule technique for manipulating the cytoskeleton. LUMICKS' C-TrapTM combines the best of both worlds to truly enable real-time visualization of cytoskeletal research.

Double microspheres pull the fluorescently labeled microtubules to a linear shape, then reduce the force applied to the right microspheres and observe the dynamic changes of the microtubules.

Visualization of DNA conformation changes
The processes of DNA transcription, translation, and repair are not only related to specific enzymatic reactions, but also include changes in the kinetics of DNA itself. DNA "breathing" is a typical DNA movement, which refers to the spontaneous process of DNA helix from double-stranded to two single strands. The open DNA single strand can provide a binding site for the corresponding enzyme. Since this process is very short-lived and spontaneous, a highly sophisticated measurement system is required for research. LUMICKS' C-TrapTM reflects the DNA "breathing" process with its sub-nm spatial resolution.
DNA "breathing" process at 65pN Monitoring DNA "breathing" for a long time (520s)
The Quantum Design China subsidiary will conduct a global tour of the product in the next few months. If you are interested, please contact us at /78 ! At the same time, we also offer free sample testing opportunities, free for your trial in the order of appointment!
For more contact information, please click: "Contact us"

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