The pharmacological effects of Pinellia
Pharmacological effects
1. Antitussive effect: raw decoction of Pinellia ternata, Pinellia ternata, Pinellia ternata and Pinellia ternata, 0.6-1g/kgig or iv, there is obvious cough caused by cat iodine solution injected into the chest or electrical stimulation of the laryngeal nerve The antitussive effect can be maintained for more than 5 hours. The antitussive effect of 0.6 g/kg was similar to that of codeine 1 mg/kg.
2. Inhibition of glandular secretion: Pinellia preparation ip has a significant inhibitory effect on salivary secretion caused by pilocarpine. It is also reported that saliva secretion increases first and then decreases after decoction po.
3. Antiemetic effect: Pinellia heating process or add alum, ginger preparations of various preparations, on the water to morphine, digitalis, copper sulfate-induced vomiting, have a certain antiemetic effect. The above three emetics have different mechanisms of action, and Pinellia can show antiemetic effects, presumably its antiemetic mechanism is the inhibition of vomiting center.
4. Anti-fertility effects: The anti-fertility rate of the first trimester mice was 0.25 mg/ml (0.9% NaCl) sc0.2 ml. After the crystalline Pinellia protein is denatured by 6M guanidine hydrochloride, stepwise dialysis (ie, diluting the denaturant with equal volume of the buffer) is used to restore the balance of Pinellia protein in physiological saline. After removing the denaturant, the protein can be renaturalized. Restore its original vitality. The recovery rate of Pinellia protein in different reversal conditions was between 69-88% of mice resistant to early pregnancy, and only one reversal condition was 5-8°C. The rate of inhibition of pregnancy was only 36%.
5. Inhibition of trypsin: Pinellia trypsin inhibitor only inhibits the hydrolysis of amides, esters, hemoglobin, and casein by trypsin and does not inhibit chymotrypsin, bradykinin, bacillin, and papain Hydrolysis of the respective substrate. The inhibitory ratios of inhibitors to porcine trypsin hydrolysis of amide, ester, hemoglobin, and casein were 1:0.71, 1:0.8, 1:0.71, and 1:0.71, respectively. From the chemical molecular size range, Pinellia trypsin inhibitor should be a macromolecular inhibitor.
6. Pharmacological effects of processed products: Qing Banxia (according to the Chinese Pharmacopoeia 85 year edition method) decoction 200% concentration 26.5ml/kg prophylactic administration, there is obvious ventricular arrhythmia induced by strontium chloride in rats Counteracting effect (P<0.05). Mouse ip60g/kg had a significant effect on locomotor activity (P<0.05). Ip15g/kg or 30g/kg can significantly increase the sleep rate of hypnotic doses of pentobarbital sodium (P<0.05). There was a tendency to prolong the sleep time of pentobarbital sodium, but it was not statistically significant. Large doses have a slight tendency to confront electroconvulsions. A dose of 30 ml/kg ig significantly inhibited (P<0.05) the secretion of pilocarpine 5 mg/kg on saliva.
6. The role of anti-cancer: pharmacological experiments showed that the dilute alcohol or aqueous leachate of Pinellia palmata has significant inhibitory effects on experimental tumors and Hela cells. The fenugreekine base obtained from the water-soluble fraction also has a significant inhibitory effect on mouse liver cancer (HCA). The β-sitosterol and analogues contained therein also have anti-tumor effects. And can obviously promote the gradual shedding of cancer cells and make the cancer shrink or disappear. The observation of clinical pharmacology is effective for cervical cancer, and the effect of local cleaning is obvious.
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