Small Molecular API Cabozantinib S-Malate (CAS No.: 1140909-48-3)
2018-10-24 17:01:02
Model NO.: Pharmacopoeial grade
Trademark: NEWBIO
Transport Package: Aluminum Foil Bags
Specification: SGS
Origin: China
HS Code: 0000000000
Model NO.: Pharmacopoeial grade
Trademark: NEWBIO
Transport Package: Aluminum Foil Bags
Specification: SGS
Origin: China
HS Code: 0000000000
Chemical Information
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Product Name | CABOZANTINIB S-MALATE |
Molecular Formula | C32H30FN3O10 |
Molecular Weight | 635.59 |
Storage | Store at -20°C  |
Targets | METXLÂ Â Â Â Â VEGFR-2Â Â Â Â Â Â Â Â KITÂ Â Â Â Â Â Â Â Â Â Â Â Â FLT3Â Â Â Â Â Â Â Â Â Â Â Â AXL |
IC50 | 7.8 μM      1.9 μM          5.0 μM       7.5 μM          42μM |
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Description
Cabozantinib malate is a potent inhibitor of MET andVEGF receptor2 with IC50 values of 1.3nM and 0.035nM.
Cabozantinib is a pan-tyrosine kinase inhibitor and is developed as an oral treatment of various cancers including MTC, GBM, NSCLC, pancreatic carcinoma, breast and colon cancer. The targets of cabozantinib are MET, VEGFR-2, RET, FLT3, KIT, AXL as well as TEK. In cellular assays, cabozantinib inhibits the phosphorylation of MET, VEGFR2, KIT, FLT3 and AXL with IC50 values of 7.8, 1.9, 5.0, 7.5 and 42μM, respectively.Â
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Application
As a pan-tyrosine kinase inhibitor, cabozantinib can affect many biological processes. Cabozantinib inhibits the tubule formation of HMVEC cells with IC50 value of 6.7nM. In B16F10 cells, cabozantinib inhibits HGF-inducedmigration and invasion with IC50 values of 31nM and 9nM, respectively. Moreover, cabozantinib shows anti-proliferation efficacy in a variety of tumors such as SNU-5, Hs746T, MDA-MB-231 and U87MG. It is also reported that the combination of cabozantinib and gefitinib can cause potent inhibition of the gefitinib-resistant HCC827GR6 cell line.
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Other Small molecular API:
AZD9291 | 1421373-65-0 |
E7080 | 417716-92-8 |
Afatinib diMaleate | 439081-18-2 |
XL184 S-MALATE | 1140909-48-3 |
Crizotinib | 877399-52-5 |
Axitinib | 319460-85-0 |
WZ4002 | 1213269-23-8 |
Vandetanib | 443913-73-3 |
Sunitinib | 557795-19-4 |
Regorafenib | 755037-03-7 |
Imatinib | 152459-95-5 |
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Shipping Condition Evaluation sample solution :Â ship with blue ice
All other available size: ship with RT , or blue ice upon request
Â
Delivery:
1) Products can be sent out within 24 hours after payment.Â
2) Secure and discreet shipment.Â
3) Various methods for your choice, like DHL/TNT/FedEx/SF-express.
Commitment:
1. We are manufacturer with own factory and we sale this product at a best quality and low price.
2. This product is available in stock, please contact the sale for more details.
3. We have QA & QC department to guarantees the ex-factory product pass rate can reach 100%.Â
====================================================
2. This product is available in stock, please contact the sale for more details.
3. We have QA & QC department to guarantees the ex-factory product pass rate can reach 100%.Â
====================================================
Contactct:
Telephone: +86-027-87002705
Mobile:Â +86-13638641831 +86-13277093700
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Â
Â
FaceBook:Â https://www.facebook.com/newbiopharma/
Website:Â Â http://www.newbiopharm.com/
Online Store:Â http://biocar.en.made-in-china.com/
©Wuhan Newbio Pharm-Tech Co., Ltd.
Newbio is a reliable supplier and looks for a long term business relationship!!!
Newbio is a reliable supplier and looks for a long term business relationship!!!
Chemical Information
Â
Product Name | CABOZANTINIB S-MALATE |
Molecular Formula | C32H30FN3O10 |
Molecular Weight | 635.59 |
Storage | Store at -20°C  |
Targets | METXLÂ Â Â Â Â VEGFR-2Â Â Â Â Â Â Â Â KITÂ Â Â Â Â Â Â Â Â Â Â Â Â FLT3Â Â Â Â Â Â Â Â Â Â Â Â AXL |
IC50 | 7.8 μM      1.9 μM          5.0 μM       7.5 μM          42μM |
Â
Â
Description
Cabozantinib malate is a potent inhibitor of MET andVEGF receptor2 with IC50 values of 1.3nM and 0.035nM.
Cabozantinib is a pan-tyrosine kinase inhibitor and is developed as an oral treatment of various cancers including MTC, GBM, NSCLC, pancreatic carcinoma, breast and colon cancer. The targets of cabozantinib are MET, VEGFR-2, RET, FLT3, KIT, AXL as well as TEK. In cellular assays, cabozantinib inhibits the phosphorylation of MET, VEGFR2, KIT, FLT3 and AXL with IC50 values of 7.8, 1.9, 5.0, 7.5 and 42μM, respectively.Â
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Application
As a pan-tyrosine kinase inhibitor, cabozantinib can affect many biological processes. Cabozantinib inhibits the tubule formation of HMVEC cells with IC50 value of 6.7nM. In B16F10 cells, cabozantinib inhibits HGF-inducedmigration and invasion with IC50 values of 31nM and 9nM, respectively. Moreover, cabozantinib shows anti-proliferation efficacy in a variety of tumors such as SNU-5, Hs746T, MDA-MB-231 and U87MG. It is also reported that the combination of cabozantinib and gefitinib can cause potent inhibition of the gefitinib-resistant HCC827GR6 cell line.
Â
 Â
Other Small molecular API:
AZD9291 | 1421373-65-0 |
E7080 | 417716-92-8 |
Afatinib diMaleate | 439081-18-2 |
XL184 S-MALATE | 1140909-48-3 |
Crizotinib | 877399-52-5 |
Axitinib | 319460-85-0 |
WZ4002 | 1213269-23-8 |
Vandetanib | 443913-73-3 |
Sunitinib | 557795-19-4 |
Regorafenib | 755037-03-7 |
Imatinib | 152459-95-5 |
Â
Shipping Condition Evaluation sample solution :Â ship with blue ice
All other available size: ship with RT , or blue ice upon request
Â
Delivery:
1) Products can be sent out within 24 hours after payment.Â
2) Secure and discreet shipment.Â
3) Various methods for your choice, like DHL/TNT/FedEx/SF-express.
Commitment:
1. We are manufacturer with own factory and we sale this product at a best quality and low price.
2. This product is available in stock, please contact the sale for more details.
3. We have QA & QC department to guarantees the ex-factory product pass rate can reach 100%.Â
====================================================
2. This product is available in stock, please contact the sale for more details.
3. We have QA & QC department to guarantees the ex-factory product pass rate can reach 100%.Â
====================================================
Contactct:
Telephone: +86-027-87002705
Mobile:Â +86-13638641831 +86-13277093700
Â
Â
Â
Â
FaceBook:Â https://www.facebook.com/newbiopharma/
Website:Â Â http://www.newbiopharm.com/
Online Store:Â http://biocar.en.made-in-china.com/
©Wuhan Newbio Pharm-Tech Co., Ltd.
Newbio is a reliable supplier and looks for a long term business relationship!!!
Newbio is a reliable supplier and looks for a long term business relationship!!!
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