Specific new genes unravel the mechanism of super bacterial resistance
Methicillin-resistant Staphylococcus aureus threatens global public health. Researchers such as Ignacio Mir-Sanchez, Department of Biochemistry and Molecular Biology, University of Chicago, USA, have discovered several new functions in the Staphylococcal Chromosome (SCC) family that have specific functions in Staphylococcus DNA replication. A gene in which the LP1413 gene encodes a single-stranded DNA (ssDNA) binding protein. By studying the crystal structure of LP1413, it was found that it uses a wing-helix-turn-helix fold in replication instead of the commonly seen oligonucleotide-binding fold. And unlike the previously found wing-helix-turn-helical domain, this time it carries a hydrophobic pocket. These findings will provide new ideas for drugs that fight super bacteria.
Anesthesia Medical Co., Ltd. , https://www.jssinoanesthesias.com