Intestinal bacteria "running" may induce autoimmune diseases

2023-10-18 11:07:53

March 13, 2018 Source: Xinhuanet

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A new study in the United States found that an intestinal bacterium "runs" to other organs, triggering an autoimmune response that can effectively reduce its effects on the immune system. This finding provides new ideas for the treatment of chronic autoimmune diseases such as systemic lupus erythematosus and autoimmune liver disease.

Autoimmune diseases are a type of disease caused by self-attacks of the immune system. Previous studies have shown that intestinal bacteria are associated with autoimmune diseases, but how they work is not known.

Researchers at Yale University School of Medicine reported in a new issue of the journal Science that they found that a bacterium called Enterococcus faecium in the intestines of mice and humans would "run around" and transfer to the liver. Tissues and organs such as the spleen cause autoimmune diseases.

When investigating mice susceptible to autoimmune diseases, the researchers found that Enterococcus gallinarum causes the body to produce autoantibodies in the tissues outside the intestines, triggering an inflammatory response. In addition, the researchers found the same inflammatory mechanism in healthy human liver cells, and found Enterococcus faecalis in the liver of patients with autoimmune diseases.

Further experiments have shown that the use of antibiotics or specific vaccines can effectively inhibit the growth of this bacterium, reduce its impact on the immune system, and inhibit autoimmunity in mice.

The researchers said that they will continue to study Enterococcus gallinarum and its mechanism of action, and hope that in the future, antibiotics can be used to treat autoimmune diseases and vaccination to improve the quality of life of patients.

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