MI enters the operating room from the laboratory to accurately locate cancer cells
In 2013, John VFrangioni, a professor at Harvard Medical School in the United States, proposed that near-infrared fluorescence imaging technology can provide effective help for clinicians, and it will be very promising in oncology in the next decade. In China, MI has entered the operating room from the laboratory, which has made this vision a reality.
For nearly a century, human access to cancer information has continued to innovate: from X-rays at the beginning of the last century to CT in the 1970s to nuclear magnetic resonance (MRI) at the beginning of this century, with these devices, people are not only cancerous I can see it clearly, and I can see it more accurately.
Innovation is endless. The optical molecular imaging surgical navigation system (MI) developed by the Institute of Automation of the Chinese Academy of Sciences not only treats cancer cells early, but unlike the above three methods, MI can accurately locate cancer cells from the molecular level during surgery. "navigation".
"The appearance is not good" MI
"This is the first generation of optical molecular imaging surgical navigation system, which is the latest product prototype." At the Institute of Automation, Chinese Academy of Sciences, assistant researcher Wang Kun introduced the new and old generations of MI equipment to the journal of the Chinese Journal of Science and Technology. MI looks "appreciative": ordinary LCD screens, brackets, lenses, movable boxes, the appearance of "moderate and modest", not as good as Medical Equipment such as nuclear magnetic resonance.
In fact, MI has great connotation and strength. "The latest MI equipment has been clinically applied in many hospitals such as the People's Liberation Army General Hospital (301 Hospital)," said Wang Kun. Whether it is the detection of microscopic tumors in the liver cancer, or the precise positioning of breast cancer, stomach cancer and sentinel lymph nodes, MI has shown great skill.
Surgery is still one of the most effective ways to treat cancer. The precise positioning of tumor boundaries has plagued clinicians and researchers. Usually, doctors rely on experience to remove tumor tissue, if less cut may cause recurrence, and more cut will cause harm to patients. "So, a method of providing objective tumor boundaries during surgery has important clinical application value." Wang Kun said.
MI is the first clinical detection device for the early accurate positioning of tumors successfully developed in China. In less than three years, it has successfully diagnosed and treated more than 100 patients with cancer, and achieved a major breakthrough in the clinical application of optical molecular imaging technology.
The operating room came "new partner"
In 2008, Nobel Prize-winning chemistry scholar Professor Qian Yongjian mentioned in the report of the World Molecular Imaging Conference in 2009 that the acquisition of objective tumor boundary information during surgery provides important value for surgical treatment. This is also a further affirmation of the widespread application of molecular imaging navigation technology.
How is molecular imaging navigation technology implemented in the human body? Chi Chongzhen, an assistant researcher at the Institute of Automation, explained that when a lesion occurs in a human lesion, the target of certain protein targets or enzyme molecules is generated outside the tumor cells. By injecting a molecular probe with fluorescent or radionuclide labeling, the probe can be automatically imaged in vivo by the specific binding of the ligand and the receptor, so that the in vivo imaging can be realized by the imaging device, thereby Reflects the changes in tumors in the body.
Chi Chongzhen began researching molecular imaging with the researcher Tian Jie. At that time, they took the first optical molecular imaging surgical navigation system out of the Key Laboratory of Molecular Imaging of the Chinese Academy of Sciences and came to the Cancer Hospital of Shantou University. The first MI device, which was not so "beautiful", became the new guy in the operating room.
Root reports that for patients with stage I and II breast cancer, if they are detected and treated early, their 5-year survival rate can reach more than 80%. The guidelines for clinical practice clearly indicate that patients with negative axillary lymph nodes in early stage (stage I or II) of breast cancer must undergo a sentinel lymph node biopsy. “The MI device we developed can objectively display the boundary information of tumors and other lesions during surgery, which provides effective help for clinicians.†Chi Chongxi said that they accurately performed sentinel lymph nodes in 22 patients with early breast cancer. Surgical navigation resection experiments. This set of experimental data was validated with the histopathological gold standard, the detection rate was 100%, and the patient did not have any adverse reactions.
With the further development of technology, the optical molecular imaging surgical navigation method can be applied to breast cancer tumors and micrometastases on the one hand, and the intraoperative molecular typing of different subtypes of breast cancer can be realized. The purpose of pathology; on the other hand, the method can be applied not only to breast cancer, but also to various cancers such as liver cancer, lung cancer, and gastric cancer, and to achieve breakthroughs in molecular imaging techniques for different tumors.
Go out of the lab and practice "iron bones"
Innovation is not the brain to come up with, it takes a team to accumulate and explore for a long time, MI is just like this. It not only integrates the knowledge of optics, physics, computer and other disciplines, but also has a "squatting bone" that can withstand clinical tests after leaving the laboratory.
When I first went to the operating room of the University Hospital, MI began to be a bit "unacceptable." “Can you turn off the shadowless lamp for a while? Can you equip the operating room with blackout curtains?†The request of Chi Chongzhen made the medical staff in the operating room feel a little embarrassed.
This is because MI needs to collect fluorescence, and the intensity of fluorescence is only one thousandth of that of natural light. In the lead chamber laboratory where the fingers are not visible, the researchers can collect fluorescence very conveniently, but it is not easy to collect in the operating room by various light sources.
After that, the Tianjie team continued to communicate with doctors and nurses and finally got their understanding and support. More importantly, researchers have overcome this problem by improving their technical skills.
Another development challenge is the algorithm. Through the basic research on the theory and method of optical molecular imaging surgical navigation system, the researchers of the Institute of Automation have developed high-order approximate mathematical models and fast dynamic imaging algorithms based on biological tissue specificity, and established a relatively complete, systematic optical molecular imaging surgery. Navigation data fusion method. The system prototype developed in the previous stage has obtained the qualified test report of the China Food and Drug Administration Institute of the State Food and Drug Administration, which verifies the safety and effectiveness of the system.
In addition, MI has selected more advanced fluorescent dyes. They combine the properties of the new molecular fluorescent dye, indocyanine green (ICG), to provide real-time fluorescence images and color images during surgery. In the actual clinical trial, about 3 minutes after the injection of ICG, the doctor can see the location of the sentinel lymph node. In this way, the doctor accurately positions the MI according to the guidance of the MI to accurately remove the sentinel lymph node tissue. After the resection, the doctor can also judge whether there is fluorescence residual and whether the accurate resection is achieved according to the fluorescence feedback.
The constantly improving MI is now a weapon in many hospital operating rooms: 301 hospital doctors can use MI for accurate detection of hilar cholangiocarcinoma in molecular imaging; in the Eastern Hepatobiliary Surgery Hospital, doctors can use this device for liver cancer portal vein Detection of cancerous plugs; doctors at Zhujiang Hospital use MI to perform microscopic tumor detection of intraoperative cirrhosis; doctors at Xijing Hospital use this device to perform precise positioning of sentinel lymph node biopsy in gastric cancer surgery.
Interventional Accessories,Introducer Sheath Kit,Hydrophilic introducer sheath,PTFE coated guide wire,Y-Valve set
Anesthesia Medical Co., Ltd. , https://www.trustfulmedical.com