Nature: Light, erase mouse memory

Release date: 2015-09-21

In a research report published in the internationally renowned journal Nature , scientists from the United States and Japan have developed a new type of device that can alter the nerve dendritic spines in the brain of mice, while the nerve dendrites Spines can be modified for the first time in events that promote memory formation, so the study suggests that by altering the dendritic spines in the brain, it may be possible to promote the memory that has been formed in the brain to be forgotten.

As part of understanding the function of the human brain, scientists are now shifting their focus to studying sub-categories in the brain, one of which is memory, how is memory formed, stored, altered, and controlled? It is still a puzzle in the scientific community, but with the latest work, biomedical researchers may be one step closer to the truth.

In this study, the researchers taught the mice to stay on a rolling tube, then used a light beam to illuminate part of the brain of the mouse, and as the mouse learns to change the beam, this operation may be The mouse brain is returned to its pre-learning state, causing the mouse to forget what has just been learned. To achieve this goal, the researchers then designed and built a special device, AS-PaRac, which is a photoelectron probe that promotes changes in the dendritic spines that grow at the edge of the dendrites in the brain. Changing the signal input between neurons, previous studies have shown that neuronal dendrites can grow and help to store the newly formed memories.

Using this new device, scientists trained mice for the first time to learn how to stay on rolling tubes, and researchers have discovered that dendrites or special dendrites that store memory can actually grow; researchers can take advantage of it. The AS-PaRac device facilitates the return of dendritic spines to the size before learning to balance on the tube, and the results indicate that such an operation can cause the mouse to forget what was learned; to ensure that such changes in the mouse occur separately, the research team Repeated, in the second study, the researchers taught the mouse another stunt, which reduced the skills of the same dendritic spine to make the mouse forget the first learning again.

Researcher Lu finally said that we believe that it will not take long to use AS-PaRac equipment to create larger dendritic spines, which will help mice learn how to stay on rolling tubes without being taught. .

Source: Bio Valley

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